Neuroimaging tools for brain edema

Characterize secondary brain injury

We develop novel neuroimaging tools to better quantify brain edema and blood-brain barrier integrity in the setting of cerebral ischemia. By creating high specificity methods using non-invasive imaging, we have advanced our understanding of the role brain edema plays in modulating neurological recovery after stroke. These studies have revealed that brain edema may impact recovery in up to 25% of all stroke patients. Our imaging tools not only provide insight into the pathophysiology of secondary brain injury, but can also serve as intermediate endpoints in clinical trials as part of proof of concept studies for anti-edema treatments.

We hypothesize that brain edema is associated with a cycle of neuronal injury. The initial ischemic insult occurs with thromboembolic blood vessel occlusion. The resulting hypoperfusion leads to tissue infarction. Brain edema, which ensues 12 to 48 hours after the initial ischemic injury, exacerbates hypoperfusion, which in turn amplifies neuronal loss within the existing stroke lesion. We believe this cascading cycle of hypoperfusion and infarction leads to greater brain injury and ultimately, worse neurological function. Using stroke cohorts with serial brain MRI imaging, our studies seek to build evidence for each segment of this cycle.

Related Publications:

Reperfusion after ischemic stroke is associated with reduced brain edema
2017
Irvine HJ, Ostwaldt A-C, Bevers MB, Dixon S, Battey TWK, Campbell BCV, Davis SM, Donnan GA, Sheth KN, Jehan R, Saver JL, Kidwell CS and Kimberly WT. J Cereb Blood Flow Metab, (2017). view PDF
Early neurological stability predicts adverse outcome after acute ischemic stroke
2016
  1. Irvine HJ, Battey TWK, Ostwaldt A-C, Campbell BCV, Davis SM, Donnan GA, Sheth KN and Kimberly WT. Int J Stroke, 11:882-889 (2016).
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Brain edema predicts outcome after non-lacunar ischemic stroke
2014
  1. Battey TWK, Karki M, Singhal AB, Wu O, Sadaghiani S, Campbell BCV, Davis SM, Donnan GA, Sheth KN and Kimberly WT. Stroke, 45:3643-3648 (2014).
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Glyburide is associated with attenuated vasogenic edema in stroke patients
2013
  1. Kimberly WT, Battey TWK, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ and Sheth KN. Neurocrit Care, 20:193-201 (2014).
view PDF