Projects

Our primary focus in clinical trials is the prevention of cerebral edema, testing the hypothesis that the sulfonylurea receptor 1 (Sur1) mediates edema formation after stroke. The clinical development of the Sur1 inhibitor, intravenous glyburide, began with a Phase 2a pilot clinical trial (GAMES-Pilot Trial), which evaluated the safety and efficacy of intravenous glyburide for the […]

We develop novel neuroimaging tools to better quantify brain edema and blood-brain barrier integrity in the setting of cerebral ischemia. By creating high specificity methods using non-invasive imaging, we have advanced our understanding of the role brain edema plays in modulating neurological recovery after stroke. These studies have revealed that brain edema may impact recovery in […]

A major tool we use is metabolite profiling (“metabolomics”), a liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique that measures >200 metabolites simultaneously. We have used this approach to study the acute stress hyperglycemia response after stroke, discovering a link between hyperglycemia, brain cytotoxic injury and subsequent brain edema formation. We have also applied the technique to […]

Although inflammation after ischemic stroke is a well-described phenomenon and hypothesized to play a key role in secondary injury, the underlying mechanisms are not well understood. Our screens have identified a role for soluble ST2 as an inflammatory biomarker that is elevated following acute ischemic stroke. Our studies have highlighted that soluble ST2 predicts functional outcome, mortality […]