Our patient-oriented investigation is the starting point for our research. Through metabolomic and proteomic screens, we identify candidate markers for secondary brain injury. Leading candidates that are independently associated with outcome and tightly linked to secondary brain injury are selected for further study. In order to determine whether there is a causal link between the biomarker and brain injury, we use rodent stroke and cell models to elucidate underlying mechanisms. Our work relies on a robust foundation of fundamental research conducted in other laboratories that study basic mechanisms of biology. From this perspective, our research has a translational focus, attempting to link basic biology to clinically relevant pathophysiology.
Below are some examples of our work investigating candidate mechanisms of secondary brain injury.