Post-stroke inflammation and brain injury

Identify candidate pathways

Although inflammation after ischemic stroke is a well-described phenomenon and hypothesized to play a key role in secondary injury, the underlying mechanisms are not well understood. Our screens have identified a role for soluble ST2 as an inflammatory biomarker that is elevated following acute ischemic stroke. Our studies have highlighted that soluble ST2 predicts functional outcome, mortality and risk of hemorrhagic transformation, and these associations are independent from traditional clinical risk factors.

Soluble ST2 is a decoy receptor in the IL-33/ST2 pathway, which is a member of the Toll-like/Interleukin-1 receptor superfamily.  Prior immunological studies of ST2 have shown that the soluble form antagonizes normal IL-33 signaling and alters the balance away from anti-inflammatory type 2 helper T cells and towards pro-inflammatory type 1 helper T cells. Our laboratory is currently investigating soluble ST2 as a candidate mechanism of post-stroke inflammatory injury.

Related Publications:

Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke
2017
Wolcott Z, Batra A, Bevers MB, Sastre C, Khoury J, Sperling M, Meyer BC, Walsh KB, Adeoye O, Broderick JP, and Kimberly WT. Ann Clin Transl Neurol, 4:553-563 (2017). view PDF